منابع مشابه
The enteroinsular axis.
Rediscovery of the role of the gastrointestinal tract in the control of carbohydrate metabolism and, as we now know, fat and protein metabolism, was made independently in London by two groups of workers (Dupre, 1964a; McIntyre et al., 1964). The major credit undoubtedly belongs to McIntyre and his colleagues (1964, 1965) who, by the simplest of methods, namely comparing the glycaemic and insuli...
متن کاملGhrelin and the enteroinsular axis in healthy men.
OBJECTIVE Ghrelin, a potent stimulator of GH secretion, also acts as an orexigenic hormone. Plasma ghrelin levels rise before meals with postprandial reduction, suggesting that circulating levels of enteroinsular hormones might influence ghrelin secretion. AIM The aim of this study was to evaluate the effects of ghrelin on enteroinsular hormones in healthy men. DESIGN Three tests were perfo...
متن کاملEquine hyperinsulinemia: investigation of the enteroinsular axis during insulin dysregulation.
Compared with some other species, insulin dysregulation in equids is poorly understood. However, hyperinsulinemia causes laminitis, a significant and often lethal disease affecting the pedal bone/hoof wall attachment site. Until recently, hyperinsulinemia has been considered a counterregulatory response to insulin resistance (IR), but there is growing evidence to support a gastrointestinal etio...
متن کاملAdaptive Human CDKAL1 Variants Underlie Hormonal Response Variations at the Enteroinsular Axis
Recent analyses have identified positively selected loci that explain differences in immune responses, body forms, and adaptations to extreme climates, but variants that describe adaptations in energy-balance regulation remain underexplored. To identify variants that confer adaptations in energy-balance regulation, we explored the evolutionary history and functional associations of candidate va...
متن کاملGlucose-dependent insulinotropic polypeptide receptor null mice exhibit compensatory changes in the enteroinsular axis.
The incretins glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are gut hormones that act via the enteroinsular axis to potentiate insulin secretion from the pancreas in a glucose-dependent manner. Both GLP-1 receptor and GIP receptor knockout mice (GLP-1R(-/-) and GIPR(-/-), respectively) have been generated to investigate the physiological importance of th...
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ژورنال
عنوان ژورنال: Journal of Clinical Pathology
سال: 1978
ISSN: 0021-9746
DOI: 10.1136/jcp.s1-8.1.38